Biology Of The Heart & Blood Vessels

The heart and blood vessels constitute the cardiovascular (circulatory) system. The blood circulating in this system delivers oxygen and nutrients to the tissues of the body and removes waste products from the tissues.

The Biology Of The Heart & Blood Vessels

The heart, a hollow muscular organ, is located in the center of the chest. The right and left sides of the heart each have an upper chamber (atrium), which collects blood and pumps it into a lower chamber (ventricle), which pumps blood out.

To ensure that blood flows in only one direction, each ventricle has an “in” (inlet) valve and an “out” (outlet) valve. In the left ventricle, the inlet valve is the mitral valve, and the outlet valve is the aortic valve.  In the right ventricle, the inlet valve is the tricuspid valve, and the outlet valve is the pulmonary (pulmonic) valve. Each valve consists of flaps (cups or leaflets), which open and close like one-way swinging doors. The mitral valve has two cups; the others (tricuspid, aortic, and pulmonary) have three. The large inlet valves (mitral and tricuspid) have tethers – consisting of the papillary muscles and cords of tissue which prevent the valves from swinging backway into the atria. If a papillary muscle is damaged (for example, by a heart attack), the valve may then swing backwards and start leaking. If a valve opening is narrowed, blood flow through the valve is reduced. A valve may have both problems.

The heartbeats are evidence that the heart is pumping. The first sound (the lub of lub-dub) is the sound of the mitral and tricuspid valves closing the second sound (the dub) is the sound of the aortic and pulmonary valves closing. Each heartbeat has two parts: diastole and systole. During diastole, the ventricles relax and till with blood; then the atriacontract, forcing more blood into the ventricles. During systole, the ventricles contract and pump blood, and the atria relax and begin filling with blood again.

Function of the heart

The heart’s only function is to pump blood. The right side of the heart pumps blood to the lungs, where oxygen is added to the blood and carbon dioxide is removed from it. The left side pumps blood to the rest of the body, where oxygen and nutrients are delivered to tissues and waste products (such as carbon dioxide) and transferred to the blood for removal by other organs (such as the lungs and kidneys).

Blood travels the following circuit: Blood from the body, which is depleted of oxygen and laden with carbon. Flows through the two largest vents (the venae cavae) into the right atrium. When the right ventricle relaxes, blood in the right atrium pours through the tricuspid valve into the right ventricle. When the right ventricle is nearly full, the right atrium contracts, propelling additional blood into the right ventricle, which then contracts. This contraction propels blood through the pulmonary valve into the pulmonary arteries, which supply the lungs. In the lungs, blood flows through the tiny capillaries that surround the air sacs. Here, the blood absorbs oxygen and gives up carbon dioxide, which is then exhaled.

Blood from the lungs, which is now oxygen-rich flows through the pulmonary veins into the left atrium. When the left ventricle relaxes, the blood in the left atrium pours through the mitral valve into the left ventricle. When the left ventricle is nearly full, the left atrium contracts, propelling additional blood into the left ventricle, which then contracts. (In the older people, the left ventricle does not fill as well before the left atrium contracts, making this contraction of the left atrium especially important. The contraction of the left ventricle propels blood through the aortic valve into the aorta, the largest artery in the body. This blood carries oxygen to all of the body except to the lungs.

The circuit through the right side of the heart, the lungs, and the left atrium is called the pulmonary circulation. The circuit through the left side of the heart, most of the body, and the right atrium is called the systemic circulation.

Blood supply of the heart

Like all organs, the heart needs a constant supply of oxygen-rich blood. A system of arteries and veins, called the coronary circulation, supplies the heart muscle (myocardium) with oxygen-rich blood and then returns oxygen-depleted blood to the right atrium. The right coronary artery and the left coronary artery branch off the aorta (just after it leaves the heart) to deliver oxygen-rich blood to the heart muscle. These two arteries branch into other arteries, including the circumflex artery, that also supply blood to the heart. The cardiac veins collect blood from the heart muscle and empty it into a large vein on the back surface of the heart called the coronary sinus, which returns the blood to the right atrium. Because of the great pressure exerted in the heart as it contracts, most blood flows through the coronary circulation only while the heart is relaxing between beats (during diastole).

Regulation of the heart

The contraction of the muscle fibers in the heart is very organized and highly controlled. Rhythmic electrical impulses (discharges) flow through the heart in a precise manner along distinct pathways and at a controlled speed. The impulses originate in the heart’s pacemaker (the sinus or sinoatrial node – a small mass of tissue in the wall of the right atrium) which generates a tiny electrical current.

The rate at which the pacemaker sends out its impulses (and thus governs the heart rate) is determined by two opposing systems – one to speed the heart rate up (the sympathetic division of the nervous system) and one to slow it down (the parasympathetic division. The sympathetic division works through a network of nerves called the sympathetic plexus and through the hormones epinephrine (adrenaline) and norepinephrine (noradrenaline), which are released by the adrenal glands and the nerve endings. The parasympathetic division divides works through a single nerve – the vagus nerve – which releases the neurotransmitter acetylcholine.

The flood vessels consist of arteries, arterioles, capillaries, venules, and veins. All blood is carried in these vessels. The arteries, which are strong, flexible, and resilent, carry blood away from the heart and bear the highest blood pressures. Because arteries are elastic, they narrow (recoil) passively when the heart is relaxing between heats and thus help maintain blood pressure. The arteries branch into smaller and smaller vessels, eventually becoming very small vessels called arterioles. Arteries and arterioles have muscular walls that can adjust their diameter to increase or decrease blood flow to a particular part of the body.

Capillaries are tiny, extremely thin-walled vessels that act as a bridge between arteries (which carry blood away from the heart) and veins (which carry blood back to the heart). The thin walls of the capillaries allow oxygen and nutrients to pass from the blood into tissues and allow waste products to pass from tissues into the blood.

Blood flows from the capillaries into very small veins called venules, then into the veins that lead back to the heart. Veins have much thinner walls than do arteries, largely because the pressure in veins is so much lower. Veins can widen (dilate) as the amount of fluid in them increases. Some veins, particularly veins in the legs, have valves in them, to prevent blood from flowing backward. When these valves lea, the back-flow of blood can cause the veins to stretch and become elongated and convoluted (tortuous). Stretch, nortuous veins near the body’s surface are called varicose veins.

If a blood vessel breaks, tears, or is cut, blood leaks out, causing bleeding. Blood may flow out of the body, as external bleeding, or it may flow into the spaces around organs or directly into organs, as internal bleeding.

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